Desempeño del índice proteína/creatinina para predecir proteinuria significativa en pacientes con sospecha de preeclampsia

Abstract

Objective: To assess the performance of the protein/creatinine index to predict proteinuria significantly and secondarily, to find the best cut-off point that had better sensitivity and specificity. Methods: Diagnostic test study developed in a cross-sectional design of patients exposed to the hypertensive syndrome of pregnancy who did or did not develop posterior preeclampsia. 173 patients were selected non-probabilistically. The new cutoff of protein/creatinine index was found using the ROC curve, we calculated sensitivity, specificity, positive and negative prediction value, positive and negative likelihood ratios and find the Spearman correlation with 24 hours urine proteinuria. Data analysis was performed using STATA software version 13. Results: The new cutoff was 0.39 with 68.3% sensitivity, specificity 73.5%, positive prediction value 91.3%, negative prediction value 36.2%, likelihood ratios (+) 2.58, likelihood ratios (-) 0.43 and an area under the curve of 0.7799. Excellent correlation was obtained with 24 hours proteinuria (rs =0.9308, p=0.000). Conclusion: Although the new cutoff for the protein/creatinine index is different from conventional, this conventional this is more specific and therefore may be useful in the outpatient management on patients with low suspicious of preeclampsia in our population.