Cell-selective particle radiation, boron neutron capture therapy and treatment of symptomatic radiation necrosis in the brain by anti-angiogenic agent

Abstract

Boron neutron capture therapy (BNCT) has been advocated as a novel particle radiation therapy for malignant tumors that targets tumor cells biologically. Since 2002, we have applied this unique radiotherapy for 133 malignant gliomas and malignant meningiomas at our institution. In addition, we recently applied anti-angiogenic agents aggressively for intractable symptomatic radiation necrosis in the brain.Here is our latest comprehensive data regarding these unique treatments, including those I presented at the 32nd annual meeting of the Japanese Neurosurgical Congress, along with some new findings.