Antibiotics from basidiomycetes. XXXI. Aleurodiscal: An antifungal sesterterpenoid from aleurodiscus mirabilis (BERK. & CURT.) höhn

Abstract

Aleurodiscal, an antifungal antibiotic has been isolated from mycelial cultures of Aleurodiscus mirabilis (Berk. & Curt.) Höhn. It causes abnormal apical branchings of Mucor miehei hyphae at very low concentrations. The structure and absolute configuration of the antibiotic has been determined by a single crystal X-ray analysis and hydrolysis to d-(+)- xylose. Aleurodiscal is a hydroxysesterterpene aldehyde β-d-xyloside with a novel carbon skeleton. © 1989, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.