Formulation and Development of Tara Gum-mediated Tablets for Delivery of Anticancer Drugs

Abstract

Background: Natural polysaccharide tara gum (TG) has been investigated for several biological uses. The current study involved the administration of imatinib, an anticancer model medication, via TG. Methods: Imatinib-modified release tablets were developed using a direct compression method with different concentrations of TG and other excipients. Compressed tablets were evaluated for physicochemical properties. Result: All formulations had an in vitro disintegration time ranging from 10-23 min. Among the formulations, F6 exhibited excellent extended-release behaviour with 72% release over 12 h. TG tablets were rich in phytoconstituents, including saponins, tannins, phenolics, flavonoids, carbohydrates, proteins, and amino acids. Conclusion: TG has potential in the drug delivery application of anticancer medications as a rate-retarding polymer.