The establishment of biological reference intervals of nontraditional glycemic markers in a Chinese population

Abstract

Background: We established the reference intervals for glycated albumin (GA), fructosamine (FA), and 1,5-anhydroglucitol (1,5-AG) in a Chinese healthy population. Methods: This study enrolled a total of 458 eligible reference individuals, consisted of 226 men and 232 women, aged from 20~79 years (median age 43 years), who attending routine healthy checks. We stratified the subjects according to gender (males and females) and age (20-39, 40-59, and 60-79 years), and combined statistical methods with Lahti algorithm, as well as appropriate clinical consideration, to judge whether partitioning for data was needed. Results: Glycated albumin levels between males and females were statistically different (P .05). The reference interval for FA was 220-298 μmol/L. Conclusion: New reference intervals for nontraditional glycemic markers were established based on a Chinese population.