Abstract
Tannic acid was found to be a highly potent inhibitor of human placenta aldose reductase. The most potent inhibitory component of the tannic acid was isolated and identified as penta-O-galloyl-3-D-glucose, which showed an ic50value of 70 nM. The inhibition by the gallotannin was reversible and of mixed type with respect to DL-glyceraldehyde as the varied substrate. © 1989, The Pharmaceutical Society of Japan. All rights reserved.
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Sawada, H., Hamatake, M., Hara, A., Nakagawa, M., & Nakayama, T. (1989). Inhibition of human placenta aldose reductase by tannic acid. Chemical and Pharmaceutical Bulletin, 37(6), 1662–1664. https://doi.org/10.1248/cpb.37.1662
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