Adenovirus cores can function as templates in in vitro DNA replication.

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Abstract

Adenovirus cores prepared by gentle disruption of virus by heating at 56 degrees C in the presence of deoxycholate were able to function as templates in an in vitro DNA replication system, allowing both initiation, indicated by the formation of terminal protein-dCMP complex, and elongation of > 300 nucleotides. Using both cores and DNA-protein complexes as templates, it was also demonstrated that novobiocin, an inhibitor of DNA gyrase, inhibited in vitro DNA replication by preventing formation of the initiation complex.

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Goding, C. R., & Russell, W. C. (1983). Adenovirus cores can function as templates in in vitro DNA replication. The EMBO Journal, 2(3), 339–344. https://doi.org/10.1002/j.1460-2075.1983.tb01428.x

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