Synthesis and adrenolytic activity of new propanolamines

Abstract

The synthesis of (2R, S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)- 3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R, S)-1-(4-methoxy-6- (methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for α1-, α2-and β1-adrenoceptor binding affinity.