Effect of fenugreek (Trigonella foenum graecum) seed aqueous extract on blood glucose, lipid profile and some hormonal assay istreptozotocin-induced diabetic male albino rats

Abstract

Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia over a prolonged period, since a long time, diabetes has been treated with plant medicines, one of these important plants is Trigonella foenum-graecum (fenugreek), thus, the investigation goals of this study to clarify the role of fenugreek seed aqueous extract in its therapeutic dose on blood glucose, triglycerides, total cholesterol, lower density lipoprotein(LDL), higher density lipoprotein (HDL),very lower density lipoprotein(VLDL), liver and kidney function by estimating alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea and serum creatinine, also to clarify the role in treatment of infertility by estimating lutilising hormone (LH), follicle stimulating hormone (FSH), testosterone hormone level, sperm count, motility and viability in Stereptozotocin induced diabetes rat for 4 weeks of treatment, 60 adult male albino rats were divided into 4 groups (15 rat for each group), control (normal rats received normal saline), diabetic rats without treatment,diabetic rats were treated with 300 mg/kg of methanolic plant extract for 4 weeks, diabetic rats treated with 650mg/kg of metformin drug. The result indicated that after 4 weeks of treatment of fenugreek seed aqueous extract, there was an improvement in blood glucose, lipid profile, liver, and kidney function. Although there was an improvement in LH, FSH, testosterone hormone, sperm count, viability and motility.