Impact of Contactless Apoptosis-Inducing RF on Temperature of Human Skin Surface and Subcutaneous Layer as well as Porcine Histology: A Pilot Study

  • Goo B
  • Kim D
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Abstract

Background and Objectives Radiofrequency (RF) technology has been developed as a noninvasive method to reduce subcutaneous abdominal fat. The aim of this study was to measure the changes of human skin surface temperature and human subcutaneous fat layer temperature, as well as to evaluate the histologic change in porcine adipocytes during and after treatment with contactless apoptosis-inducing RF device. Materials and Methods A single pig was treated with RF device for 30 minutes at maximum power of 200 Watts. The skin was biopsied and evaluated immediately after the therapy. A female human volunteer was also treated with RF device for 45 minutes. The temperatures of the skin surface and subcutaneous fat layer were measured during the therapy. Results Skin biopsy specimens from the pig revealed changes in the adipocyte shape and size. Many of the adipocytes had shrunken, with a few showing consensed chromatin and fragmented nuclei, reflecting signs of adipocyte apoptosis. In the human volunteer, subcutaneous fat layer maintained a temperature of 43-45 o C, while the skin surface temperature did not reach 43 o C during the treatment. Conclusion The contactless selective RF device achieved the ideal temperature for fat reduction in subcutaneous fat layer during the treatment, while maintaining skin surface temperate below the threshold of heat-induced pain for humans. Apoptosis of subcutaneous adipocytes was confirmed in porcine skin. Further clinical trials are necessary to evaluate the efficacy and safety.

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Goo, B., & Kim, D. S. (2016). Impact of Contactless Apoptosis-Inducing RF on Temperature of Human Skin Surface and Subcutaneous Layer as well as Porcine Histology: A Pilot Study. Medical Lasers, 5(1), 29–33. https://doi.org/10.25289/ml.2016.5.1.29

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