In angiogenesis, tight control of endothelial tip cell selection and migration drives new blood vessel branching. Page et al. show that VEGF-signaling-mediated positive feedback shapes the timing, magnitude, and robustness of tip cell identity decisions. Moreover, they identify a key modulator of VEGF-mediated positive feedback, Tm4sf18, which temporally controls angiogenesis in vivo.
Page, D. J., Thuret, R., Venkatraman, L., Takahashi, T., Bentley, K., & Herbert, S. P. (2019). Positive Feedback Defines the Timing, Magnitude, and Robustness of Angiogenesis. Cell Reports, 27(11), 3139-3151.e5. https://doi.org/10.1016/j.celrep.2019.05.052