Synthesis, spectroscopic and toxicity studies of titanocene chelates of isatin-3-thiosemicarbazones

Abstract

The reactions of bis(cyclopentadienyl)titanium(IV) dichloride with a new class of thiosemicarbazone(LH2), derived by condensing isatin with different N(4)-substituted thiosemicarbazides, have been studiedand products of type [Cp2Ti(L)] have been isolated. On the basis of various physico-chemical and spectralstudies, five coordinate structures have been assigned to these derivatives. Toxicity studies of titanocenecomplexes at tbur different concentrations have been carried out against snail Lymnaea acuminata. Theeffect of most potent compounds on the activity of acetylcholinesterase enzyme, which inhibits the activity ofenzyme, possibly by the formation of enzyme-inhibitor complex, was also studied.