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Naturally arising CD25+CD4+ regulatory T cells in tumor immunity

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Naturally arising regulatory T (TR) cells, represented by CD25+CD4+ TR cells, play an essential role in maintaining immunological self-tolerance. This T cell-mediated dominant control of the immune response not only inhibits the development of autoimmune disease, but also impedes effective immunosurveillance against autologous tumor cells. Attenuation of TR cell-mediated immune suppression can therefore evoke effective tumor immunity in otherwise nonresponsive animals. This common regulatory mechanism for autoimmunity and tumor immunity can be exploited when devising a novel immunotherapy for cancer. © Springer-Verlag Berlin Heidelberg 2005.




Nomura, T., & Sakaguchi, S. (2005). Naturally arising CD25+CD4+ regulatory T cells in tumor immunity. Current Topics in Microbiology and Immunology. Springer Verlag.

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