Impact of Achyranthes aspera L. on Protein Profile in Impaired Wound Models

Abstract

In the present study, comparative protein profile of granulation tissues of burn, diabetic and immunocompromised wounds treated with 5.0% (w/w) ointment of methanol extract of Achyranthes aspera was undertaken. Granulation tissue of A. aspera treated group showed expression of a protein with molecular weight 69.4 kD in burn wound and proteins ranging from high, medium and low molecular weight (61.0, 55.0 and 31.5kD) in diabetic and immunocompromised wounds. A. aspera treatment induced expression of a particular protein of molecular weight 31.5 kD in both diabetic and immunocompromised wound models, signifying that this particular protein might play a key role in A. aspera mediated wound healing in these two models. © 2011 IGJPS. All rights reserved