Genetic Aspects of Chronic and Aggressive Periodontitis

Abstract

Evidence suggests that there is some genetic basis for the periodontal diseases. The molecular abnormality and its genetic inheritance has been established in some cases of generalized aggressive periodontitis. Family studies indicates that this disorder is transmitted by autosomal recessive genes. Recent evidence also suggests that susceptibility to periodontal disease may be related in part to genetically determined immune responsiveness to bacteria. Although specific genetic risk factors have not been identified for the chronic periodontitis, recent studies indicate that there is significant genetic variance in the population. More precise definitions of disease phenotypes will facilitate future genetic epidemiologic studies of the periodontal diseases.