Recent Advances in Ultrasound Assisted Synthesis of 2,4,5-Trisubstituted Imidazoles: A Comparative Study of Effective Catalytic Systems

Abstract

The imidazole moiety finds itself in a host of compounds having profound biological and medicinal properties. This has led to the quest to develop a cost effective, and desirably greener synthetic route to access this azole. In this review, ultrasonic irradiation assisted syntheses of trisubstitued imidazole derivatives have been discussed which make use of different environment friendly and efficient catalytic systems. They have been found to give excellent yield of product having high purity and with a shorter reaction time and has proved to be a viable alternative to traditional methods.