Synthesis and turnover rates of four rat liver mitochondrial RNA species

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Abstract

The synthesis and turnover rates of the two 12 S and 16 S mt rRNAs and of the mt mRNAs for subunits I and III of cytochrome oxidase have been determined by measuring the kinetics of incorporation of [3H]uridine in the mtRNA of rat hepatocytes. All the RNA species examined have approximately the same turnover (t1 2 ~ 100 min) and therefore the rate of synthesis, which is about 10-times higher for the rRNAs, seems to be the factor responsible for the different mt rRNA and mRNA steady-state levels. © 1987.

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Cantatore, P., Flagella, Z., Fracasso, F., Lezza, A. M. S., Gadaleta, M. N., & de Montalvo, A. (1987). Synthesis and turnover rates of four rat liver mitochondrial RNA species. FEBS Letters, 213(1), 144–148. https://doi.org/10.1016/0014-5793(87)81480-1

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