The neuro-inflammatory perspectives on the application and utilization of ursodeoxycholic acid in schizophrenia

Abstract

Various research methods to treat schizophrenia have experienced conflicting etiological theories through their evolution, with diverse emphasis on genetic, physiological, biochemical, and psychological aspects. However, major breakthroughs have not been reached despite decades of research on schizophrenia. This article aims to provide perspectives on research findings and cast light on the potential involvement of bile acid metabolism in schizophrenia and its impacts on the neuro-inflammatory response. These results can be exploited to identify new leads for drug treatment through an enhanced understanding of disease pathophysiology.