Solid-phase synthesis of new trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers

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Abstract

Trp(Nps)-Lys-NH2 derivatives, bearing alkyl or guanidine groups either at the N-terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists. © 2010 by the authors; licensee MDPI, Basel, Switzerland.

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Pérez de Vega, M. J., García-López, M. T., Zaccaro, L., Royo, M., Albericio, F., Fernández-Carvajal, A., … González-Muñiz, R. (2010). Solid-phase synthesis of new trp(Nps)-containing dipeptide derivatives as TRPV1 channel blockers. Molecules, 15(7), 4924–4933. https://doi.org/10.3390/molecules15074924

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