Square Wave Voltammetric Determination of 2‐Thiouracil in Pharmaceuticals and Real Samples Using Glassy Carbon Electrode

Abstract

A simple and rapid method was developed using cyclic and square wave voltammetric techniques for the determination of trace‐level sulfur containing compound, 2‐thiouracil, at a glassy carbon electrode. 2‐thiouracil produced two anodic peaks at 0.334 V and 1.421 V and a cathodic peak at −0.534 V. The square wave voltammetry of 2‐thiouracil gave a good linear response in the range of 1–20 μ M with a detection limit of 0.16 μ M and quantification limit of 0.53 μ M (0.0679 μ g/g), which is in good agreement as per IUPAC definition of trace component analysis (100 μ g/g). The obtained recoveries range from 98.10% to 102.1%. The proposed method was used successfully for its quantitative determination in pharmaceutical formulations and urine as real samples.