Cationic gold(l) axially chiral biaryl bisphosphine complex-catalyzed atropselective synthesis of heterobiaryls

Abstract

It has been established that a cationic gold(I)/(R)-DTBM-Segphos or (R)-BINAP complex catalyzes the atropselective intramolecular hydroaiylation of alkynes leading to enantioenriched axially chiral 4-aryl-2-quinolinones and 4-arylcoumarins with up to 61% ee. © 2011 Shibuya et al.