Synthesis of o-brominated diaryl ethers using symmetrical iodonium salts:Application to the synthesis of Bastadin precursors

Abstract

The coupling of o-brominated phenols with symmetrical iodonium salts for the construction of the corresponding diaryl ethers was studied. Bis-(2-benzyloxy-5-formyl-phenyl)-iodonium bromide 6b, only once mentioned in the literature, was fully characterized and tested for the synthesis of Bastadin related diaryl ethers.