Catalytic Alkyne/Alkene-Carbonyl Metathesis: Towards the Development of Green Organic Synthesis

Abstract

The construction of carbon-carbon bond through the metathesis reactions between carbonyls and olefins or alkynes has attracted significant interest in organic chemistry due to its high atom-economy and efficiency. In this regard, carbonyl–alkyne metathesis is well developed and widely used in organic synthesis for the atom-efficient construction of various carbocycles and heterocycles in the presence of catalytic Lewis acids or Brønsted acids. On the other hand, alkene-carbonyl metathesis is recently developed and has been a topic of great importance in the field of organic chemistry because they possess attractive qualities involving metal-mediated, metal-free intramolecular, photochemical, Lewis acid-mediated ring-closing metathesis, ring-opening metathesis and cross-metathesis. This review covers most of the strategies of carbonyl–alkyne and carbonyl–olefin metathesis reactions in the synthesis of complex molecules, natural products and pharmaceuticals as well as provides an overview of exploration of the metathesis reactions with high atom-economy as well as environmentally and ecologically benign reaction conditions.