TGF-β1 -509C/T polymorphism and susceptibility to keloid disease: a systematic review and meta-analysis

Abstract

Lay summaryKeloid scars are thick and lumpy scars that behave almost like tumours. They grow, are unsightly and itchy, and difficult to treat as they can get worse after attempts at treating them. This article reviews the scientific evidence for a link between a certain gene variation, specifically `509C/T polymorphism in the TGF-β1 gene’. After an extensive scientific database search, five studies were found, and no significant association was detected between the TGF-β1 -509C/T polymorphism and Keloid scarring. High quality and large-scale studies are needed to validate our findings.