Cu-Catalyzed Cross-Dehydrogenative ortho-Aminomethylation of Phenols

Abstract

A highly selective CuII-catalyzed cross-dehydrogenative ortho-aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp2)−C(sp3) coupling products were obtained in moderate to excellent yields under mild reaction conditions and with a broad substrate scope. A radical mechanism is proposed.