Receptors for glucocorticoids in the human inner ear

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Abstract

Glucocorticoid receptors were detected in the human inner ear. The highest concentration of glucocorticoid receptor protein was measured by enzyme-linked immunosorbent assay in the spiral ligament tissues; the lowest concentration of glucocorticoid receptors was measured in the macula of the saccule. The demonstration of the presence of glucocorticoid receptors in human inner ear tissues provides a basis to consider the direct effects of glucocorticoid action on select inner ear cells, rather than assuming a systemic antiinflammatory or immunosuppressive effect during the therapeutic treatment of patients with given inner ear disorders.

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Rarey, K. E., & Curtis, L. M. (1996). Receptors for glucocorticoids in the human inner ear. Otolaryngology - Head and Neck Surgery, 115(1), 38–41. https://doi.org/10.1016/S0194-5998(96)70133-X

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