Use of bioresorbable fibers for short-wave infrared spectroscopy using time-domain diffuse optics

Abstract

We demonstrate the usability of bioresorbable phosphate glass fibers for time-domain diffuse optical spectroscopy (TD-DOS) in the short-wave infrared (SWIR) region of 950–1600 nm, with the use of an InGaAs detector. Bioresorbable fibers for diffuse optics present an exciting prospect due to their ability to be left implanted while retrieving optical properties from deeper regions (few cm) for monitoring treatments. Extending TD-DOS to the SWIR region could be useful to better identify biomarkers such as water, lipids and collagen, given their increase in absorption in this range. We attempt to use the bioresorbable fibers to spectrally identify these biomarkers by measuring a series of biological samples known to contain them, such as porcine muscle, porcine fat and bone. We further validate our measurements by comparing the optical properties of high-scattering solid silicone phantoms retrieved with these bioresorbable fibers with those by a standard Si fiber.