Synthetic medicinal chemistry in chagas' disease: Compounds at the final stage of "hit-to-lead" phase

Abstract

Chagas' disease, or American trypanosomosiasis, has been the most relevant illness produced by protozoa in Latin America. Synthetic medicinal chemistry efforts have provided an extensive number of chemodiverse hits at the "active-to-hit" stage. However, only a more limited number of these have been studied in vivo in models of Chagas' disease. Herein, we survey some of the cantidates able to surpass the "hit-to-lead" stage discussing their limitations or merit to enter in clinical trials in the short term. © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. © 2010 by the authors.