Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis

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The objective was to determine plasma levels of pro- (IL-12p70/IL-6) and anti-inflammatory (IL-10) cytokines before and after cycle ergometer training in healthy control (HC) and people with multiple sclerosis (pwMS), and to correlate plasma cytokines with physical/mental health. Study participants cycled for 30 min at 65–75% age-predicted maximal heart rate, twice a week for 8 weeks during supervised sessions. We determined that plasma IL-10 expression was lower in pwMS, compared to HCs, and that exercise augmented IL-10 in pwMS to baseline levels in HCs. Furthermore, plasma isolated from pwMS displayed enhanced expression of the pro-inflammatory cytokines IL-12p70/IL-6. Plasma cytokine signatures correlated with physical/mental health. Overall, this study highlights the potential of a short-term exercise programme to regulate circulating cytokine profiles with relevance to pwMS.




Barry, A., Cronin, O., Ryan, A. M., Sweeney, B., O’Toole, O., O’Halloran, K. D., & Downer, E. J. (2019). Cycle ergometer training enhances plasma interleukin-10 in multiple sclerosis. Neurological Sciences, 40(9), 1933–1936.

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