YUA001, a novel aldose reductase inhibitor isolated from alkalophilic Corynebacterium sp. YUA25. I. Taxonomy, fermentation, isolation and characterization

Abstract

YUA001 is a novel aldose reductase inhibitor produced from alkalophilic Corynebacterium sp. YUA25 isolated from soil. YUA001 was purified from the supernatant of culture broth by successive silica gel column chromatography, Sephadex LH20-100 gel column chromatography, and HPLC. From instrumental analysis, molecular formula of YUA001 is C13H19NO2 and its molecular weight is 221. It exhibits potent aldose reductase inhibition activity and has no antimicrobial activity against some Gram-positive or Gram-negative bacteria, fungi and yeast.