The Coapsys device to treat functional mitral regurgitation: In vivo long-term canine study

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Abstract

Objective: We evaluated the capability of the Myocor Coapsys device (Myocor. Inc. Maple Grove, Minn) to reduce functional mitral regurgitation in a canine model of dilated cardiomyopathy. Methods: Functional mitral regurgitation with heart failure was induced in 7 dogs by rapid ventricular pacing. The Coapsys device. which consists of anterior and posterior epicardial pads connected by a subvalvular chord, was then implanted. Heart failure was maintained by continued pacing for 8 weeks. Hemodynamic and echocardiographic measurements were performed at pre- and post-sizing and after 8 weeks. The Coapsys subvalvular chord was cut to verify that maintenance of valve competency was due to the device. Results: All implants were performed off-pump without atriotomy. Mitral regurgitation was reduced in all animals; mean mitral regurgitation grade was reduced from 2.9 ± 0.7 to 0.7 ± 0.8 (P = .00005) and was maintained at 0.8 ± 0.8 after 8 weeks, without hemodynamic compromise or structural damage to the mitral valve. Mitral regurgitation returned to 3.6 ± 0.8 (P = .102 versus presizing) after cutting the Coapsys subvalvular chord. Conclusion: The Coapsys device consistently and chronically reduced functional mitral regurgitation. This device is in clinical trials in the United States.

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Inoue, M., McCarthy, P. M., Popović, Z. B., Doi, K., Schenk, S., Nemeh, H., … Filsoufi, F. (2004). The Coapsys device to treat functional mitral regurgitation: In vivo long-term canine study. Journal of Thoracic and Cardiovascular Surgery, 127(4), 1068–1077. https://doi.org/10.1016/j.jtcvs.2003.12.005

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