Local acoustic field enhancement of single cell photoacoustic signal detection based on metamaterial structure

Abstract

The photoacoustic signal from single cell plays an important role in medical diagnosis. Currently, the single-cell photoacoustic detection has limitations. To overcome the limits, an acoustic metamaterial model based on the acoustic waveguide theory for local enhancement of the ultrahigh frequency (UHF) acoustic signals was implemented in this study and it was applied to study the acoustic signal characteristics of individual cells. The local field enhancement effect at different frequencies and the specific mechanism of the model was evaluated in the simulation experiment. This proposing acoustic metamaterial structure of good practical value can be used in various applications for acoustic signal processing.