Potential of dual-time-point imaging to improve breast cancer diagnosis with 18F-FDG PET

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Abstract

The purpose of this study was to assess the utility of dual-time-point imaging for identifying malignant lesions in the breast by 18F-FDG PET. Methods: Fifty-four breast cancer patients with 57 breast lesions underwent 2 sequential PET scans (dual-time-point imaging). The average percent change in standardized uptake values (SUVs) between time point 1 and time point 2 was calculated. All PET study results were correlated with follow-up surgical pathology results. Results: Of the 57 breast lesions, 39 were invasive carcinoma and 18 were postbiopsy inflammation. Among the invasive carcinoma lesions, 33 (85%) showed an increase and 6 (15%) showed either no change or a decrease in SUVs over time. The percent change in SUVs from time point 1 to time point 2 (mean ± SD) was ± 12.6% ± 11.4% (P = 0.003). Of the 18 inflammatory lesions, 3 (17%) showed an increase and 15 (83%) showed either no change or a decrease in SUVs. The percent change in SUVs from time point 1 to time point 2 (mean ± SD) was -10.2% ± 16.5% (P = 0.03). Of the 57 normal contralateral breasts, 2 (3.5%) showed an increase and 55 (96.5%) showed either no change or a decrease in SUVs. The percent change in SUVs from time point 1 to time point 2 (mean ± SD) was -15.8% ± 17% (P = 0.005). Conclusion: There is increasing uptake of 18F-FDG over time in breast malignancies, whereas the uptake of 18F-FDG in inflammatory lesions and normal breast tissues decreases over time. A percent change of +3.75 or more in SUVs over time is highly sensitive and specific in differentiating inflammatory lesions from malignant lesions.

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APA

Kumar, R., Loving, V. A., Chauhan, A., Zhuang, H., Mitchell, S., & Alavi, A. (2005). Potential of dual-time-point imaging to improve breast cancer diagnosis with 18F-FDG PET. Journal of Nuclear Medicine, 46(11), 1819–1824. https://doi.org/10.1016/s0098-1672(08)70048-1

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