Historically, key cellular regulators of diverse physiological processes have been uncovered by studying the mechanisms by which chemical entities produce interesting biological phenotypes. In this issue, Dixon et al. interrogate compounds that selectively kill oncogene-expressing cells, providing support for the existence of an iron-requiring, regulated form of cell death, ferroptosis. © 2012 Elsevier Inc.
Reed, J. C., & Pellecchia, M. (2012, May 25). Ironing out cell death mechanisms. Cell. Cell Press. https://doi.org/10.1016/j.cell.2012.05.009