Ursolic acid enhances nitric oxide and tumor necrosis factor-α production via nuclear factor-κB activation in the resting macrophages

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Abstract

Ursolic acid (UA), a pentacyclic triterpene acid, is reported to have anti-tumor activities; however, the mechanism underlying its anti-tumorigenic effects is poorly understood. To further determine the mechanism of UA, we investigated the effects of UA on the release of nitric oxide (NO) and tumor necrosis factor-α (TNF-α), and on the level of inducible nitric oxide synthase (iNOS) and TNF-α gene expression in mouse resting macrophages. We found that UA elicited a dose-dependent increase in NO and TNF-α production, and the level of iNOS and TNF-α mRNA. Transient expression and electrophoretic mobility shift assays with nuclear factor-κB (NF-κB) binding sites revealed that the increased level of iNOS mRNA and TNF-α mRNA induced by UA were mediated by the NF-κB transcription factor complex. These results demonstrate that UA stimulates NO and TNF-α release and is able to upregulate iNOS and TNF-α expression through NF-κB transactivation in the resting macrophages. © 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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You, H. J., Choi, C. Y., Kim, J. Y., Park, S. J., Hahm, K. S., & Jeong, H. G. (2001). Ursolic acid enhances nitric oxide and tumor necrosis factor-α production via nuclear factor-κB activation in the resting macrophages. FEBS Letters, 509(2), 156–160. https://doi.org/10.1016/S0014-5793(01)03161-1

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