Effects of mesoporous calcium magnesium silicate on setting time, compressive strength, apatite formation, degradability and cell behavior to magnesium phosphate based bone cements

Abstract

Mesoporous calcium magnesium silicate was doped into magnesium phosphate to fabricate magnesium phosphate based composite cements (MBC). The results showed that the setting time was significantly prolonged from 4 min to 11 min while the compressive strength decreased from 17 MPa to 9 MPa. In addition, the apatite formation ability improved in simulated body fluid (SBF) and degradation of the composite cements in Tris-HCl solution increased with the increase of m-CMS content of the MBC. Importantly, the MBC with excellent cytocompatibility remarkably promoted the MC3T3-E1 cells proliferation and differentiation, which depended on the m-CMS content. It can be suggested that MBC with good bioactivity, degradability and cytocompatibility has great potential to serve as implanted cements for bone defect filler and repairs.