Chaetoglobosins, Cytotoxic 10-(Indol-3-yl)-[13]cytochalasans from Chaetomium spp. IV. 13C-Nuclear Magnetic Resonance Spectra and Their Application to a Biosynthetic Study

Abstract

Assignments of the 13C-nuclear magnetic resonance signals of eight naturally occurring chaetoglobosins were established.' Incorporations of [1-13C]-,[2-13C]-, and [l,2-13C2]-acetate, [13C-methyl]-L-methionine, and [1-13C]- and [2-13C]-DL-tryptophan into chaetoglobosins A and C by Chaetomium globosum demonstrated that the molecules were formed from nine units of acetate/malonate, three C1 units, and one unit of tryptophan. © 1983, The Pharmaceutical Society of Japan. All rights reserved.