Aim. The present study aims to analyze the potential role of VEGF +936 C/T polymorphism in cervical intraepithelial neoplasia. Material and Method. One hundred and eighty-six patients were included in the study: 75 cases (patients diagnosed with CIN) and 111 controls (negative for both HPV testing and cytology). For each patient a single visit was scheduled when colposcopy was performed. From cervical specimen, cytology and HPV testing were performed and from peripheral blood VEGF +936 genotyping was determined. For statistical analysis purposes OR and chi-square were used at a level of significance of <0.05. Results. No link has been found in the detection of CT genotype in cases versus controls, OR = 0.8295, [0.42, 1.62]. An inverse correlation has been found between T allele and HSIL, OR = 0.2121, [0.0473, 0.9517], p=0.0866. Conclusion. No link has been found between VEGF +936 C/T and cervical intraepithelial neoplasia.
Rotar, I. C., Dumitras, D. E., Popp, R. A., Petrisor, F. M., Cotutiu, P., Stamatian, F., & Muresan, D. (2016). VEGF +936 C/T Genetic Polymorphism in Patients with Cervical Dysplasia. Analytical Cellular Pathology, 2016. https://doi.org/10.1155/2016/6074275