O5‐04‐03: Regular multimodal aerobic exercise reduces pro‐inflammatory cytokines and improves BDNF peripheral levels and executive functions in elderly MCI individuals with different BDNF Val66Met genotypes

Abstract

See, stats, and : https : / / www . researchgate . net / publication / 287123330 Regular pro - inflammatory peripheral elderly . . . Article DOI : 10 . 1016 / j . jalz . 2015 . 07 . 465 CITATIONS 0 READS 139 8, including : Some : ADAM10 - Alzheimer Carla Universidade 24 SEE Marcia Universidade 51 SEE Daniel University 37 SEE Florindo University 94 SEE All - text , letting . Available : Carla Retrieved : 10 Send Orders for Reprints to reprints@benthamscience . net Abstract : The benefits of physical exercise to reduce low - grade inflammation and improve Brain - Derived Neurotrophic Fac - tor (BDNF) levels and cognitive function became a growing field of interest . Low - grade inflammation is common during ag - ing and seems to be linked to neurodegenerative process . Regular physical exercises can help to reduce pro - inflammatory cy - tokines levels and to improve BDNF peripheral concentrations . The main goal of this research was to analyze the effects of a 16 - week multimodal physical exercise program on peripheral BDNF levels and on Tumor Necrosis - - (TNF - -) and Interleu - kin - 6 (IL - 6) as pro - inflammatory markers in cognitive healthy elderly individuals and in elderly with mild cognitive impair - ment (MCI) . Cognitive functions were assessed by the Montreal Cognitive Assessment (MoCA) prior to and after the inter - vention . Thirty cognitively healthy participants and thirty - seven MCI participants were assigned to the control (CG) and trained (TG) groups . The TG participated in a multimodal physical training program for a 16 - week period . The results showed a significant between - subjects interaction , which indicates the beneficial contribution of training on the reduction of TNF - (p=0 . 001) and IL - 6 (p<0 . 001) and on the improvement of BDNF (p<0 . 001) peripheral concentrations . Cognitive func - tions also presented significant improvements for MCI trained group (p=0 . 03) . In conclusion , physical exercise was effective to reduce pro - inflammatory cytokines and to improve BDNF peripheral levels , with positive reflexes on cognition . To the best of our knowledge , this is the first study that evaluated longitudinally the effects of a multimodal physical exercises pro - tocol on peripheral concentrations of pro - inflammatory cytokines and cognition performance in elderly MCI individuals .