The First Structures of T Cell Receptors Bound to Peptide–MHC

Abstract

The structure of the MHC class I molecule HLA-A2 reported in 1987 by Bjorkman et al. ([1][1]) had revealed how peptide Ags are presented to T cells: peptides are buried in the long and deep groove of the MHC molecule, flanked on each side by a long α helix. The structure immediately suggested that