Endothelial function is impaired in fit young adults of low birth weight

152Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

Abstract

Objective: Non-insulin-dependent diabetes, hypertension and ischaemic heart disease, with insulin resistance, are associated with low birth weight (the 'Small Baby Syndrome'). Common to these adult clinical conditions is endothelial dysfunction. We tested the hypothesis that endothelial dysfunction could precede their development in those of low birth weight. Methods: Endothelial function was measured by ultrasonic 'wall-tracking' of flow-related brachial artery dilatation in fit 19-20 year old subjects randomly selected (blind to the investigators throughout the study) from low (<2.5 kg) and normal (3.0-3.8 kg) birth weight subjects in the 1975-7 cohort of the Cardiff Births Survey and with no known cause for endothelial dysfunction. Results: Flow-related dilatation was impaired in low birth weight relative to normal birth weight subjects (median 0.04 mm [1.5%] [n=22] cf. 0.11 mm [4.1%] [n=17], p<0.05; 0.04 mm [1.5%] [n=15] cf. 0.12 mm [4.4%] [n=[2], p<0.05 after exclusion of inadvertently included ever-smokers). Conclusion: The findings suggest that endothelial dysfunction is a consequence of foetal malnutrition, consistent with contributing to the clinical features of the 'Small Baby Syndrome' in later adult life.

Cite

CITATION STYLE

APA

Goodfellow, J., Bellamy, M. F., Gorman, S. T., Brownlee, M., Ramsey, M. W., Lewis, M. J., … Henderson, A. H. (1998). Endothelial function is impaired in fit young adults of low birth weight. Cardiovascular Research, 40(3), 600–606. https://doi.org/10.1016/S0008-6363(98)00197-7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free