Negative motor phenomena in cortical stimulation: Implications for inhibitory control of human action

Abstract

Electrical stimulation of the human cortex typically elicits positive sensorimotor effects. However, many neurosurgical studies have also reported negative motor areas (NMAs) in which stimulation produces inhibition of ongoing movement. The neurocognitive implications of these studies have not been systematically explored. Here we review the neurosurgical literature on NMAs and link this to cognitive mechanisms of inhibition and their role in voluntary control of action. In particular, we discuss the functional validity of NMAs. We contest the sceptical view that negative effects following stimulation merely reflect disruption of positive motor areas. Instead, we suggest that NMAs may produce an inhibitory mechanism under ecologically valid conditions. © 2012 Elsevier Srl.