The use of D-Optimal Mixture Design in the development of date stone and spirulina tablet formulation as a phycocyanin dietary supplement

Abstract

The aim of this work is in the formulation of a dietary supplement, combining spirulina and date stone benefits. For this, a study was done on these two ingredients by determining their approximate composition and antioxidant potential. Following this, we used a statistical method to determine the appropriate proportions of ingredients to obtain a tablet with optimal physical properties. After setting these parameters, we analysed this tablet’s composition and effectiveness by evaluating its physicochemical properties, antioxidant potential, FTIR spectrum and studied the controlled release of phycocyanin. Our results revealed that the optimized formula showed high stability and richness in active compounds.