Treatment of readily available α,α-difluoro- and α-fluoroarylacetic acids with Selectfluor under Ag(I) catalysis led to decarboxylative fluorination. This operationally simple reaction gave access to tri- and difluoromethylarenes applying a late-stage fluorination strategy. Translation to [18F]labeling is demonstrated using [ 18F]Selectfluor bis(triflate), a reagent affording [ 18F]tri- and [18F]difluoromethylarenes not within reach with [18F]F2. © 2013 American Chemical Society.
CITATION STYLE
Mizuta, S., Stenhagen, I. S. R., O’Duill, M., Wolstenhulme, J., Kirjavainen, A. K., Forsback, S. J., … Gouverneur, V. (2013). Catalytic decarboxylative fluorination for the synthesis of Tri- and difluoromethyl arenes. Organic Letters, 15(11), 2648–2651. https://doi.org/10.1021/ol4009377
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