The cognitive and perceptual processes that affect observer performance in lung cancer detection: a scoping review

Abstract

Introduction: Early detection of malignant pulmonary nodules through screening has been shown to reduce lung cancer-related mortality by 20%. However, perceptual and cognitive factors that affect nodule detection are poorly understood. This review examines the cognitive and visual processes of various observers, with a particular focus on radiologists, during lung nodule detection. Methods: Four databases (Medline, Embase, Scopus and PubMed) were searched to extract studies on eye-tracking in pulmonary nodule detection. Studies were included if they used eye-tracking to assess the search and detection of lung nodules in computed tomography or 2D radiographic imaging. Data were charted according to identified themes and synthesised using a thematic narrative approach. Results: The literature search yielded 25 articles and five themes were discovered: 1 – functional visual field and satisfaction of search, 2 – expert search patterns, 3 – error classification through dwell time, 4 – the impact of the viewing environment and 5 – the effect of prevalence expectation on search. Functional visual field reduced to 2.7° in 3D imaging compared to 5° in 2D radiographs. Although greater visual coverage improved nodule detection, incomplete search was not responsible for missed nodules. Most radiological errors during lung nodule detection were decision-making errors (30%–45%). Dwell times associated with false-positive (FP) decisions informed feedback systems to improve diagnosis. Interruptions did not influence diagnostic performance; however, it increased viewing time by 8% and produced a 23.1% search continuation accuracy. Comparative scanning was found to increase the detection of low contrast nodules. Prevalence expectation did not directly affect diagnostic accuracy; however, decision-making time increased by 2.32 seconds with high prevalence expectations. Conclusion: Visual and cognitive factors influence pulmonary nodule detection. Insights gained from eye-tracking can inform advancements in lung screening. Further exploration of eye-tracking in lung screening, particularly with low-dose computed tomography (LDCT), will benefit the future of lung cancer screening.