Markers of tissue repair and cellular aging are increased in the liver tissue of patients with HIV infection regardless of presence of HCV coinfection

1Citations
Citations of this article
14Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)-related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin- embedded liver tissue for HIV-infected patients, HCV-infected patients, HIV/HCV-coinfected patients, and controls at Duke University Medical Center. De-identified sections were stained for markers against the wound repair Hedgehog (Hh) pathway, resident T-lymphocytes, and immune activation and cellular aging. HIV infection was independently associated with Hh activation and markers of immune dysregulation in the liver tissue.

Cite

CITATION STYLE

APA

Naggie, S., Swiderska-Syn, M., Choi, S., Lusk, S., Lan, A., Ferrari, G., … Diehl, A. M. (2018). Markers of tissue repair and cellular aging are increased in the liver tissue of patients with HIV infection regardless of presence of HCV coinfection. Open Forum Infectious Diseases, 5(7). https://doi.org/10.1093/ofid/ofy138

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free