In this issue of Structure, Carafoli et al. investigate the mode of antibody-mediated inhibition of the discoidin domain receptor 1 (DDR1). These studies also provide new insight into activation of the DDRs, which are unique among receptor tyrosine kinases in the composition of their extracellular regions. © 2012 Elsevier Ltd.
Ferguson, K. M. (2012, April 4). Discoidin discoveries. Structure. Cell Press. https://doi.org/10.1016/j.str.2012.03.003