Generation and characterization of novel magnetic field-responsive biomaterials

32Citations
Citations of this article
35Readers
Mendeley users who have this article in their library.

Abstract

We report the preparation of novel magnetic field-responsive tissue substitutes based on biocompatible multi-domain magnetic particles dispersed in a fibrin-agarose biopolymer scaffold. We characterized our biomaterials with several experimental techniques. First we analyzed their microstructure and found that it was strongly affected by the presence of magnetic particles, especially when a magnetic field was applied at the start of polymer gelation. In these samples we observed parallel stripes consisting of closely packed fibers, separated by more isotropic net-like spaces. We then studied the viability of oral mucosa fibroblasts in the magnetic scaffolds and found no significant differences compared to positive control samples. Finally, we analyzed the magnetic and mechanical properties of the tissue substitutes. Differences in microstructural patterns of the tissue substitutes correlated with their macroscopic mechanical properties. We also found that the mechanical properties of our magnetic tissue substitutes could be reversibly tuned by noncontact magnetic forces. This unique advantage with respect to other biomaterials could be used to match the mechanical properties of the tissue substitutes to those of potential target tissues in tissue engineering applications.

Cite

CITATION STYLE

APA

Lopez-Lopez, M. T., Scionti, G., Oliveira, A. C., Duran, J. D. G., Campos, A., Alaminos, M., & Rodriguez, I. A. (2015). Generation and characterization of novel magnetic field-responsive biomaterials. PLoS ONE, 10(7). https://doi.org/10.1371/journal.pone.0133878

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free