The Relationship of Hemogram and Inflammatory Biomarkers to Lenght of Stay in Hospital and Clinical Course in Patients with COVID-19

Abstract

Objective: It was aimed to research the relationship between neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), inflammatory markers and lenght of stay in hospital (LOS) with clinical results in hospitalized patients with Coronavirus disease-2019 (COVID-19). Methods: Total leukocyte, neutrophil, lymphocyte and platelet counts (/mm(3)), hemoglobin (g/dL), mean platelet volume, C-reactive protein (CRP) (mg/L), ferritin (ng/mL), lactate dehydrogenase (LDH) (U/L) creatine kinase (U/L), D-dimer (ng/mL), troponin-I (pg/mL), alanine aminotransferase (U/L), aspartate aminotransferase (U/L) and serum creatinine (mg/dL) measurements were recorded. NLR and PLR were calculated. Applied treatments, intensive care unit requirement, and mortality rates were determined. For LOS and mortality, the sensitivity of biochemical parameters was evaluated. Results: One hundred seventy-one patients (87 females, 84 males) were evaluated. The mean age was 57.9 +/- 14.6 years, and the mean LOS was 8.83 +/- 6.4 days. There was a positive correlation between NLR and PLR (p<0.05). NLR was correlated with CRP, LDH, ferritin, D-dimer, and troponin-I (p<0.05). LOS was longer in patients with high serum creatinine, CRP, LDH, ferritin, and troponin-I (p<0.05). The need of intensive care unit was observed in 14.6% of the patients and mortality rate was 9.9%. The most used medications were Azithromycin and Hydroxychloroquine. In patients with advanced age, prolonged LOS, and increased inflammation, the frequency of using Favipravir and Tociluzumab was higher. Conclusion: In patients with COVID-19, inflammatory parameters are useful to predict LOS. Increased NLR and PLR seem to be related with poor prognosis.