ER-mitochondria contacts: Actin dynamics at the ER control mitochondrial fission via calcium release

Abstract

The formin-like protein INF2 is an important player in the polymerization of actin filaments. In this issue, Chakrabarti et al. (2018. J. Cell Biol. https ://doi .org /10 .1083 /jcb .201709111) demonstrate that INF2 mediates actin polymerization at the endoplasmic reticulum (ER), resulting in increased ER-mitochondria contacts, calcium uptake by mitochondria, and mitochondrial division.